Tumour promoter uncouples β-adrenergic receptor from adenyl cyclase in mouse epidermis


Alterations in β-adrenergic receptor number and function and in the hormonal responsiveness of adenylate cyclase have been observed in transformed cells1–3, and tumours4,5. Phorbol myristate acetate (PMA), a potent tumour promoter in mouse skin, induces a dramatic loss of epidermal responsiveness to catecholamines in vivo6,8, although basal levels of cyclic… (More)
DOI: 10.1038/284171a0


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