Tumour necrotisation in nude mice xenografts by the reversible protein synthesis inhibitor zilascorb(2H).

@article{Pettersen1993TumourNI,
  title={Tumour necrotisation in nude mice xenografts by the reversible protein synthesis inhibitor zilascorb(2H).},
  author={Erik Olai Pettersen and Rolf Olav Larsen and John Michael Dornish and Bernt B{\o}rretzen and M. E. H. Juul and T. E. Aastveit and Jahn M. Nesland and Einar K. Rofstad and Reidar Oftebro},
  journal={British Journal of Cancer},
  year={1993},
  volume={67},
  pages={650 - 656}
}
The deuterated benzaldehyde derivative zilascorb(2H), 5,6-O-benzylidene-d-L-ascorbic acid, was administered once daily by i.v. injection in nude mice with grafted tumours of a human malignant melanoma (E.E.) and ovarian carcinoma (OVCAR-3) origins. Like benzaldehyde, zilascorb(2H) has been shown to induce protein synthesis inhibition at otherwise non-toxic doses in cells grown in vitro, and acts reversibly in the sense that protein synthesis returns to normal shortly after removal of the drug… CONTINUE READING
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