Tumour necrosis factor production in a rat airpouch model of inflammation: Role of eicosanoids

@article{Ferrndiz2005TumourNF,
  title={Tumour necrosis factor production in a rat airpouch model of inflammation: Role of eicosanoids},
  author={M. Ferr{\'a}ndiz and S. J. Foster},
  journal={Agents and Actions},
  year={2005},
  volume={32},
  pages={289-294}
}
TNF is a potent cytokine which can induce many of the pathological changes associated with inflammatory disease.In vitro studies have demonstrated that 5-lipoxygenase products promote the production of TNF by activated macrophages, suggesting that 5-lipoxygenase inhibitors may have therapeutic utility for the treatment of inflammatory conditions. A rat airpouch model of inflammation has been used to investigate the relationship between eicosanoid generation and TNF productionin vivo. Injection… Expand
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