Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence.

@article{Tobinick2009TumourNF,
  title={Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence.},
  author={Edward Lewis Tobinick},
  journal={CNS drugs},
  year={2009},
  volume={23 9},
  pages={713-25}
}
Tumour necrosis factor (TNF), a key regulator of varied physiological mechanisms in multiple organ systems, is an immune signalling molecule produced by glia, neurons, macrophages and other immune cells. In the brain, among other functions, TNF serves as a gliotransmitter, secreted by glial cells that envelope and surround synapses, which regulates synaptic communication between neurons. The role of TNF as a gliotransmitter may help explain the profound synaptic effects of TNF that have been… CONTINUE READING
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