Tumour necrosis factor microsatellites show association with multiple sclerosis.

  title={Tumour necrosis factor microsatellites show association with multiple sclerosis.},
  author={Claire W. Kirk and Aidan G. Droogan and Stanley A. Hawkins and S. A. Mcmillan and Norman Cumming Nevin and Colin A. Graham},
  journal={Journal of the neurological sciences},
  volume={147 1},
The TNF alpha and beta genes are located between the class I and class III HLA loci and have been implicated in the pathogenesis of multiple sclerosis. We carried out allelic association analysis using four microsatellite markers localised within a 20 kb region around the TNF genes. The study was performed on DNA samples from 189 clinically definite MS patients and 206 normal controls, all of Northern Irish origin. The allele distributions for the TNFa and b markers were significantly different… CONTINUE READING

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