Tumour necrosis factor gene polymorphisms are associated with COPD.

@article{Gingo2008TumourNF,
  title={Tumour necrosis factor gene polymorphisms are associated with COPD.},
  author={Matthew R. Gingo and Lori J. Silveira and York E. Miller and Adam L Friedlander and Gregory P. Cosgrove and Edward D. Chan and Lisa A Maier and Russ P Bowler},
  journal={The European respiratory journal},
  year={2008},
  volume={31 5},
  pages={1005-12}
}
Tumour necrosis factor (TNF)-alpha has been shown to be an important factor in animal models of chronic obstructive pulmonary disease (COPD). However, human studies of TNF polymorphisms in COPD have been equivocal. Six TNF single nucleotide polymorphisms (-1031C/T, -863C/A, -857C/T, -237G/A, -308G/A and +487G/A) and their haplotypes were investigated in 423 Caucasian smokers (298 patients with spirometric evidence of COPD and 125 without airflow obstruction). The -308 minor allele (A) had a… CONTINUE READING