Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity.

@article{Krner1996TumourNF,
  title={Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity.},
  author={Heinrich K{\"o}rner and Jonathan Sedgwick},
  journal={Immunology and cell biology},
  year={1996},
  volume={74 5},
  pages={
          465-72
        }
}
Tumour necrosis factor (TNF) is a highly potent, proinflammatory cytokine with broad-ranging functions from the regulation of endothelial cell adhesion molecules to facilitate entry of leucocytes into tissues, to direct induction of cellular cytotoxicity. This diversity of function potentially attributable to TNF in the genesis of inflammatory disorders place TNF as a primary candidate for clinical targeting and considerable success in this regard has been achieved, particularly in rheumatoid… CONTINUE READING

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