Tumour necrosis factor-alpha potentiates contraction of human bronchus in vitro.

@article{Sukkar2001TumourNF,
  title={Tumour necrosis factor-alpha potentiates contraction of human bronchus in vitro.},
  author={Maria B Sukkar and Jennifer M. Hughes and Carol L Armour and Paul R. Johnson},
  journal={Respirology},
  year={2001},
  volume={6 3},
  pages={
          199-203
        }
}
OBJECTIVE Chronic inflammation of the airways is an important component in the induction of airway hyperresponsiveness (AHR) in asthma. The pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) have been implicated in the induction of AHR. Whether these cytokines directly modulate the contractile properties of human airway smooth muscle (ASM) has not been fully investigated. METHODOLOGY The contractile response to acetylcholine (ACh) (10(-8) to… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

New Omega-3 Derivatives Reduce Airway Inflammation and Prevent Rho-Kinase Activation in an Allergic Model of Asthma

Caroline Morin, Samuel Fortin, Eric Rousseau
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND