Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis.

@article{Mookerjee2003TumourNF,
  title={Tumour necrosis factor alpha is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis.},
  author={Rajeshwar P Mookerjee and Sandip Sen and Nathan A. Davies and Stephen J Hodges and Roger Williams and Rajiv Jalan},
  journal={Gut},
  year={2003},
  volume={52 8},
  pages={1182-7}
}
BACKGROUND The role of proinflammatory cytokines in the pathogenesis of portal hypertension is unclear. AIMS AND METHODS This study tests the hypothesis that tumour necrosis factor alpha (TNF-alpha) is an important mediator of the circulatory disturbances in alcoholic hepatitis (AH) and evaluates the acute and short term effect of a single infusion of the monoclonal chimeric anti-TNF-alpha antibody (Infliximab) on portal and systemic haemodynamics in 10 patients with severe biopsy proven AH… CONTINUE READING

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