Tumour necrosis factor-alpha interacts with laminin and functions as a pro-adhesive cytokine.

@article{Hershkoviz1995TumourNF,
  title={Tumour necrosis factor-alpha interacts with laminin and functions as a pro-adhesive cytokine.},
  author={Rami Hershkoviz and I Goldkorn and Ofer Lider},
  journal={Immunology},
  year={1995},
  volume={85 1},
  pages={125-30}
}
Certain cytokines, chemokines and growth factors interact with components of the extracellular matrix (ECM) and, in particular, sulphated polysaccharides and proteoglycans. Recently, we demonstrated that tumour necrosis factor-alpha (TNF-alpha), an inflammatory cytokine, can bind fibronectin (FN), a cell-adhesive glycoprotein of the ECM, and that TNF-alpha bound to FN enhances the binding of T cells to the glycoprotein. In the present study, we studied the interactions of TNF-alpha and laminin… CONTINUE READING

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