Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers.

@article{Rodriguez1995TumourNF,
  title={Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers.},
  author={Purificaci{\'o}n Rodriguez and Martine Heyman and C{\'e}line Candalh and Maria Agnes Blaton and Claude Bouchaud},
  journal={Cytokine},
  year={1995},
  volume={7 5},
  pages={441-8}
}
TNF-alpha is a widely distributed proinflammatory cytokine, involved in many disease states. Although it has widely distributed effects, a precise mechanism of action has never been described, in particular at the epithelial level. Morpho-functional changes of the intestinal epithelial monolayer HT29 cl.19A exposed to TNF-alpha were therefore assessed, using electron microscopy (including freeze-fracture replica analysis), as well as measurement of mannitol, Na+ and horseradish peroxidase… CONTINUE READING