Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis.

@article{Han2007TumourNF,
  title={Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis.},
  author={Xiaobin Han and Nancy Marie Benight and Bankole O Osuntokun and Kimberly A Loesch and Stuart J. Frank and Lee A. Denson},
  journal={Gut},
  year={2007},
  volume={56 1},
  pages={73-81}
}
BACKGROUND Neutralisation of tumour necrosis factor alpha (TNFalpha) restores systemic growth hormone function in patients with Crohn's disease, and induces mucosal healing. Anabolic effects of growth hormone depend on activation of the STAT5 transcription factor. Although it has recently been reported that both administration of growth hormone and neutralisation of TNFalpha reduce mucosal inflammation in experimental colitis, whether this involved activation of STAT5 in the gut is not known… CONTINUE READING

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