Tumour necrosis factor alpha binding to human and mouse trophoblast.

  title={Tumour necrosis factor alpha binding to human and mouse trophoblast.},
  author={E Ben-Yair and Amir Less and Sima Lev and L Ben-Yehoshua and B. Tartakovsky},
  volume={9 11},
Tumour necrosis factor alpha (TNF-alpha) is a cytokine with pleiotropic effects, modulating cell growth, differentiation, and synthesis of various substances. Recent demonstration of TNF-alpha mRNA and protein in the uteroplacental unit suggests that this cytokine may be involved in the development of the embryo. To determine whether the embryo itself binds TNF-alpha, mouse blastocyst outgrowths and human first trimester villous trophoblast were analysed for TNF-alpha binding. Our experiments… CONTINUE READING