Tumour necrosis factor alpha--mediator of apoptosis and cell proliferation of hepatocytes.

In recent years, the intracellular pathways activated by the tumour necrosis factor have been described in great detail. Adaptor molecules which bind to the intracellular domain of the tumour necrosis factor receptor 1 are able to either induce apoptosis or to activate signals which trigger cell proliferation, anti-apoptotic mechanisms or the inflammatory… (More)