Tumour necrosis factor-α drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis.


Chronic renal failure involves the progressive loss of renal parenchymal cells. For example, Alport syndrome develops from mutated type IV collagen that fosters the digestion of glomerular basement membranes and podocyte loss, followed by progressive glomerulosclerosis, ie Alport nephropathy. Here we show that autosomal recessive Alport nephropathy in… (More)
DOI: 10.1002/path.2979


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