Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.

@article{Louis1998TumourNF,
  title={Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.},
  author={Edouard J. Louis and Denis Franchimont and A Piron and Y Gevaert and Nicole Schaaf-Lafontaine and S. S. RAO Roland and Philippe Mahieu and Michel Malaise and Donat de Groote and Renaud Louis and Jacques Belaiche},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={113 3},
  pages={401-6}
}
TNF-alpha is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-alpha production. This might determine a predisposition to develop some complications or phenotypes of these diseases. The aims of our study were to assess the inter-individual variability of TNF-alpha production and to correlate this variability to a single base pair polymorphism located at position -308 in TNF gene. We studied 62 healthy individuals. TNF-alpha… CONTINUE READING