Tumour necrosis factor, fever and fatality in falciparum malaria.

  title={Tumour necrosis factor, fever and fatality in falciparum malaria.},
  author={Dominic P Kwiatkowski},
  journal={Immunology letters},
  volume={25 1-3},
In Gambian children with Plasmodium falciparum infection, uncomplicated malaria fever is associated with moderately elevated circulating tumour necrosis factor (TNF) levels. We review clinical and in vitro data suggesting that schizont rupture stimulates bursts of TNF production that mediate paroxysms of malaria fever, and that the fever could possibly be beneficial to the host. Mean plasma TNF levels are ten times higher in fatal cerebral malaria than in uncomplicated malaria, providing… CONTINUE READING

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