Tumour-microenvironmental interactions: paths to progression and targets for treatment.

  title={Tumour-microenvironmental interactions: paths to progression and targets for treatment.},
  author={Carol Box and Susanne J. Rogers and Marta Mendiola and Suzanne A. Eccles},
  journal={Seminars in cancer biology},
  volume={20 3},
Primary human tumours can often be eradicated by surgery if detected early; however metastatic disease renders complete cure less likely and the development of resistance to therapy results in tumour escape and increased risk of death. Interactions of tumour cells with each other, surrounding normal cells and extracellular matrix or basement membrane components are crucial to all stages of cancer progression. Changes in both cell-cell and cell-substrate proteins are linked to tumour cell… CONTINUE READING