Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

  title={Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling},
  author={Wei Tan and Weizhou Zhang and Amy Strasner and Sergei I. Grivennikov and Jin Quan Cheng and Robert M Hoffman and Michael Karin},
Inflammatory mechanisms influence tumorigenesis and metastatic progression even in cancers whose aetiology does not involve pre-existing inflammation or infection, such as breast and prostate cancers. For instance, prostate cancer metastasis is associated with the infiltration of lymphocytes into advanced tumours and the upregulation of two tumour-necrosis-factor family members: receptor activator of nuclear factor-κB (RANK) ligand (RANKL) and lymphotoxin. But the source of RANKL and its role… CONTINUE READING
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CD41 T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

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Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumorsand lead toan adverse clinical outcome

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