Tumour-infiltrating lymphocytes mediate lysis of autologous squamous cell carcinomas of the head and neck

@article{Hald1995TumourinfiltratingLM,
  title={Tumour-infiltrating lymphocytes mediate lysis of autologous squamous cell carcinomas of the head and neck},
  author={Jesper Hald and Niels Rasmussen and Mogens Helweg Claesson},
  journal={Cancer Immunology, Immunotherapy},
  year={1995},
  volume={41},
  pages={243-250}
}
Tumour-infiltrating lymphocytes (TIL) and tumours from six patients with squamous cell carcinomas of the head and neck (SCCHN) were investigated. The six tumours all expressed major histocompatibility complex (MHC) class I antigens both in vivo and as tumor cell lines grown in vitro. In addition, the cancer cells either overexpressed the tumour-suppressor gene product p53 or harboured human papilloma virus 16/18 (HPV). The TIL were expanded in vitro in the presence of interleukin-2, immobilised… CONTINUE READING

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Generation of turnout-specific CTLs from melanoma patients by using peripheral blood stimulated with allogeneic melanoma turnout cell lines

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