Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239.

@article{Lord1998TumourIB,
  title={Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239.},
  author={Brian I. Lord and Lorna B Woolford and L-s Wang and V. A. Stones and Dorothy McDonald and Sally A. Lorimore and D. Papworth and Eric G. Wright and David Scott},
  journal={British Journal of Cancer},
  year={1998},
  volume={78},
  pages={301 - 311}
}
We have investigated the possibility that transgenerational effects from preconceptional paternal irradiation (PPI) may render offspring more vulnerable to secondary exposure to an unrelated carcinogen. 239Pu (0, 128 or 256 Bq g(-1)) was administered by intravenous injection to male mice, 12 weeks before mating with normal females. Two strains of mouse were used -- CBA/H and BDF1. Haemopoietic spleen colony-forming units (CFU-S) and fibroblastoid colony-forming units (CFU-F), a component of… CONTINUE READING
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