Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

@article{Purdie1994TumourIS,
  title={Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.},
  author={C. Purdie and David J. Harrison and Audrey Peter and Lorraine Dobbie and Sharon Andrews White and Sarah E. M. Howie and Donald Salter and Cameron C Bird and Andrew H. Wyllie and Martin Hooper},
  journal={Oncogene},
  year={1994},
  volume={9 2},
  pages={603-9}
}
In human tumourigenesis the tumour suppressor gene most commonly affected by mutation, inactivation or allele loss is p53. Loss of p53 function is associated both with failure to maintain a normal diploid status and inability to delete cells by apoptosis following DNA damage. To investigate further the role of p53 we have generated mice carrying a large deletion within the gene. All animals homozygous for this deletion develop spontaneous tumours, predominantly lymphomas, by the age of 6 months… CONTINUE READING

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