Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours


Background:Hypoxia can activate autophagy, a self-digest adaptive process that maintains cell turnover. Mammalian target of rapamycin (mTOR) inhibitors are used to treat cancer but also stimulate autophagy.Methods:Human mammary cancer cells and derived xenografts were used to examine whether hypoxia could exacerbate autophagy-mediated resistance to the mTOR… (More)
DOI: 10.1038/bjc.2013.644


5 Figures and Tables


Citations per Year

Citation Velocity: 9

Averaging 9 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.