Tumour heterogeneity and cancer cell plasticity

@article{Meacham2013TumourHA,
  title={Tumour heterogeneity and cancer cell plasticity},
  author={Corbin Elizabeth Meacham and Sean J Morrison},
  journal={Nature},
  year={2013},
  volume={501},
  pages={328-337}
}
Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny. However, it remains unclear what fraction of cancers follow the stem-cell model and what clinical behaviours the model explains. Studies using lineage tracing and deep sequencing could… CONTINUE READING
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