Tumour-growth inhibitory nitrophenylaziridines and related compounds: structure-activity relationships. II.

@article{Khan1971TumourgrowthIN,
  title={Tumour-growth inhibitory nitrophenylaziridines and related compounds: structure-activity relationships. II.},
  author={Arshad H. Khan and W. C. J. Ross},
  journal={Chemico-biological interactions},
  year={1971},
  volume={4 1},
  pages={
          11-22
        }
}
In Part I of this study it was shown that in a series of substituted 5-(1-aziridinyl)-2,4-dinitrobenzamides, the activity as inhibitors of the transplanted Walker carcinoma 256 could be correlated with the water/lipoid partition coefficient and the sensitivity of the amide linkage towards hydrolysis. To assess the relative importance of these two parameters new derivatives of this amide and some related 5-car☐ylic ester derivatives have been prepared. The results of antineoplastic assays… CONTINUE READING

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