Tumour escape from immune surveillance through dendritic cell inactivation.

  title={Tumour escape from immune surveillance through dendritic cell inactivation.},
  author={Alain P. Vicari and Christophe Caux and Giorgio Trinchieri},
  journal={Seminars in cancer biology},
  volume={12 1},
Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune system by interfering with the migration of DC or by not providing the necessary activation signals. Moreover, tumours promote the secretion of factors that inhibit DC… CONTINUE READING

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