Tumour-educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion.

@article{Karnevi2014TumoureducatedMD,
  title={Tumour-educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion.},
  author={Emelie Karnevi and Roland Andersson and Ann H. Rosendahl},
  journal={Immunology and cell biology},
  year={2014},
  volume={92 6},
  pages={543-52}
}
At the time of diagnosis, almost 80% of pancreatic cancer patients present with new-onset type 2 diabetes (T2D) or impaired glucose tolerance. T2D and pancreatic cancer are both associated with low-grade inflammation. Tumour-associated macrophages (TAMs) have a key role in cancer-related inflammation, immune escape, matrix remodelling and metastasis. In… CONTINUE READING