Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells

@article{Lewis2004TumourderivedTM,
  title={Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells},
  author={Mark P Lewis and Kate A Lygoe and Maria L Nystrom and Wally Anderson and Paul M Speight and J. F. Marshall and Gareth James Thomas},
  journal={British Journal of Cancer},
  year={2004},
  volume={90},
  pages={822 - 832}
}
The development of an altered stromal microenvironment is a common feature of many tumours including squamous cell carcinoma (SCC), and there is increasing evidence that these changes in the stroma, which include increased expression of proteases and cytokines, may actually promote tumour progression. A common finding is that stromal fibroblasts become ‘activated’ myofibroblasts, expressing smooth muscle actin and secreting cytokines, proteases and matrix proteins. We show that myofibroblasts… CONTINUE READING
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