Tumour cell survival signalling by the ERK1/2 pathway

  title={Tumour cell survival signalling by the ERK1/2 pathway},
  author={Kathryn Balmanno and Simon J Cook},
  journal={Cell Death and Differentiation},
Several advances in recent years have focused increasing attention on the role of the RAF-MEK-ERK1/2 pathway in promoting cell survival. The demonstration that BRAF is a human oncogene mutated at high frequency in melanoma, thyroid and colon cancer has provided a pathophysiological context, whilst the description of potent and highly selective inhibitors of BRAF or MEK has allowed a more informed and rational intervention in both normal and tumour cells. In addition, separate studies have… CONTINUE READING
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