Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases.

@article{Akfirat2013TumourCS,
  title={Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases.},
  author={Canan Akfirat and Xiaotun Zhang and Aviva Ventura and Dror Berel and Mary E Colangelo and Cindy K Miranti and Maryla Krajewska and John C. Reed and Celestia S. Higano and Lawrence D. True and Robert L. Vessella and Colm M Morrissey and Beatrice S. Knudsen},
  journal={The Journal of pathology},
  year={2013},
  volume={230 3},
  pages={291-7}
}
The complexity of survival mechanisms in cancer cells from patients remains poorly understood. To obtain a comprehensive picture of tumour cell survival in lethal prostate cancer metastases, we examined five survival proteins that operate within three survival pathways in a cohort of 185 lethal metastatic prostate metastases obtained from 44 patients. The expression levels of BCL-2, BCL-XL, MCL-1, cytoplasmic survivin, nuclear survivin, and stathmin were measured by immunohistochemistry in a… CONTINUE READING

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