Tumour-cell invasion and migration: diversity and escape mechanisms

@article{Friedl2003TumourcellIA,
  title={Tumour-cell invasion and migration: diversity and escape mechanisms},
  author={P. Friedl and Katarina Wolf},
  journal={Nature Reviews Cancer},
  year={2003},
  volume={3},
  pages={362-374}
}
Cancer cells possess a broad spectrum of migration and invasion mechanisms. These include both individual and collective cell-migration strategies. Cancer therapeutics that are designed to target adhesion receptors or proteases have not proven to be effective in slowing tumour progression in clinical trials — this might be due to the fact that cancer cells can modify their migration mechanisms in response to different conditions. Learning more about the cellular and molecular basis of these… Expand

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