Tumour-cell invasion and migration: diversity and escape mechanisms

  title={Tumour-cell invasion and migration: diversity and escape mechanisms},
  author={Peter Friedl and Katarina Wolf},
  journal={Nature Reviews Cancer},
Cancer cells possess a broad spectrum of migration and invasion mechanisms. These include both individual and collective cell-migration strategies. Cancer therapeutics that are designed to target adhesion receptors or proteases have not proven to be effective in slowing tumour progression in clinical trials — this might be due to the fact that cancer cells can modify their migration mechanisms in response to different conditions. Learning more about the cellular and molecular basis of these… 

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