Tumour biology: Policing of oncogene activity by p53

@article{Efeyan2006TumourBP,
  title={Tumour biology: Policing of oncogene activity by p53},
  author={Alejo Efeyan and Isabel Garc{\'i}a-Cao and Daniel Herranz and Susana Velasco-Miguel and Manuel Serrano},
  journal={Nature},
  year={2006},
  volume={443},
  pages={159-159}
}
The tumour-suppressor protein p53 provides the most important genetic defence against cancer and is activated in response to DNA damage and to oncogenic signalling, both of which occur almost universally in malignant tumours. But the relative contribution of these two pathways in inducing p53-dependent protection against cancer is unclear. Here we show that p53-dependent protection against cancer is lost in mice that have been genetically manipulated so that their p53 is activated in response… CONTINUE READING

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