Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

@article{Zhou1998TumourAK,
  title={Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation},
  author={Hongyi Zhou and Jian Kuang and Ling Zhong and Wen-Lin Kuo and Joe W. Gray and Aysegul Sahin and Bill Robert Brinkley and Subrata Sen},
  journal={Nature Genetics},
  year={1998},
  volume={20},
  pages={189-193}
}
The centrosomes are thought to maintain genomic stability through the establishment of bipolar spindles during cell division, ensuring equal segregation of replicated chromosomes to two daughter cells. Deregulated duplication and distribution of centrosomes have been implicated in chromosome segregation abnormalities, leading to aneuploidy seen in many cancer cell types. Here, we report that STK15 (also known as BTAK and aurora2), encoding a centrosome-associated kinase, is amplified and… 
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
TLDR
The results show that centrosome amplification alone is not sufficient to induce chromosomal instability in colon cancer cells with a MIN phenotype, and it has to be associated with alterations in genes regulating mitosis progression such as Aurora-A/STK15 to trigger CIN.
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TLDR
The results suggest that in Hep-2 cell line overexpression of STK15 gene may cause centrosomal amplification thereby result in chromosomal instability through abnormal mitosis, and may be one of the mechanisms underlying laryngeal carcinogenesis.
The Centrosomal Kinase Nek2 Displays Elevated Levels of Protein Expression in Human Breast Cancer
TLDR
The first study of the protein expression levels of the Nek2 kinase in human cancer cell lines and primary tumors is presented and it is found that Nek2 protein is significantly up-regulated in preinvasive in situ ductal carcinomas of the breast as well as in invasive breast carcinomas.
The Centrosomal Kinase Nek 2 Displays Elevated Levels of Protein Expression in Human Breast Cancer
TLDR
The first study of the protein expression levels of the Nek2 kinase in human cancer cell lines and primary tumors is presented and it is found that Nek2 protein is significantly up-regulated in preinvasive in situ ductal carcinomas of the breast as well as in invasive breast carcinomas.
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.
  • Donghui Li, Jijiang Zhu, S. Sen
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2003
TLDR
The results show that STK15 is overexpressed in pancreatic tumors and carcinoma cell lines and suggest that overexpression of STK 15 may play a role in Pancic carcinogenesis.
Amplification/overexpression of a mitotic kinase gene in human bladder cancer.
TLDR
STK15 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with aneuploidy and aggressive clinical behavior in human bladder cancer.
Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.
TLDR
It appears that Nek2 and Plk4 might synergize to promote breast tumorigenesis and may also be involved in tamoxifen and trastuzumab resistance.
Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.
TLDR
It is suggested that ratAurA overexpression and centrosome amplification were linked to tumor development and progression and may serve as early markers in tumorigenesis.
The centrosome-associated Aurora/Ipl-like kinase family.
Overexpression of Oncogenic STK 15 / BTAK / Aurora A Kinase in Human Pancreatic Cancer 1
TLDR
STK15 was overexpressed in all of the nine cell lines examined, but gene amplification was infrequent, and it is suggested that overexpression of STK15 may play a role in pancreatic carcinogenesis.
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