Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

  title={Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation},
  author={Hongyi Zhou and Jian Kuang and Ling Jian Zhong and Wen-Lin Kuo and Joe Gray and Aysegul Sahin and Bill R. Brinkley and Subrata Sen},
  journal={Nature Genetics},
The centrosomes are thought to maintain genomic stability through the establishment of bipolar spindles during cell division, ensuring equal segregation of replicated chromosomes to two daughter cells. Deregulated duplication and distribution of centrosomes have been implicated in chromosome segregation abnormalities, leading to aneuploidy seen in many cancer cell types. Here, we report that STK15 (also known as BTAK and aurora2), encoding a centrosome-associated kinase, is amplified and… CONTINUE READING
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