Tumour Specific Transplantation Antigens: Possible Origin in Pre-malignant Lesions

@article{Lappe1969TumourST,
  title={Tumour Specific Transplantation Antigens: Possible Origin in Pre-malignant Lesions},
  author={Markus Lappe},
  journal={Nature},
  year={1969},
  volume={223},
  pages={82-84}
}
TUMOUR specific transplantation antigens have been detected in most malignant tumours, including carcinogen-induced skin carcinomas in mice1. The existence of a morphologically identifiable precursor for such carcinomas, the papilloma, provides material for testing the prediction that the tumour specific transplantation antigens of malignant lesions derive from antigens present in pre-malignant lesions. This prediction is implicit in Burnet's concept of “immunological surveillance”2 which… CONTINUE READING