Tumors in dogs exposed to experimental intraoperative radiotherapy.

  title={Tumors in dogs exposed to experimental intraoperative radiotherapy.},
  author={Peter A. S. Johnstone and William Bradlyn Laskin and A M Deluca and M. Teresa Barn{\'e}s and Timothy J. Kinsella and William F Sindelar},
  journal={International journal of radiation oncology, biology, physics},
  volume={34 4},
PURPOSE The frequency of radiation-induced neoplasms was determined in dogs enrolled in the National Cancer Institute canine trials of intraoperative radiotherapy (IORT). METHODS AND MATERIALS Twelve protocols assessing normal tissue response to IORT involved 238 dogs in a 15-year trial. Eighty-one dogs were followed for > 24 months postoperatively and were assessed for tumor development; 59 of these animals received IORT. RESULTS Twelve tumors occurred in the 59 dogs receiving IORT. Nine… CONTINUE READING