Tumors in Nude Mice Encoding a c-myc Promoter-binding Protein ( MBP-1 ) Inhibits Human Breast Carcinoma Cells Transfected with the Gene

We have identified previously a gene from a human cervical carcinoma cell (lici,11) cDNA expression library that encodes a Mr ~37,000 c-myc promoter-binding protein (MBP-1), which binds to the TATA box se quences of c-myc P2 promoter and exerts a negative regulatory function by down-regulating c-myc expression. In normal human tissues, this cloned gene… (More)