Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination.

@article{Rofstad2010TumorsET,
  title={Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination.},
  author={Einar K. Rofstad and Jon-Vidar Gaustad and Tormod A. M. Egeland and Berit S. Mathiesen and Kanthi Galappathi},
  journal={International journal of cancer},
  year={2010},
  volume={127 7},
  pages={1535-46}
}
Clinical studies have shown that patients with highly hypoxic primary tumors may have poor disease-free and overall survival rates. Studies of experimental tumors have revealed that acutely hypoxic cells may be more metastatic than normoxic or chronically hypoxic cells. In the present work, causal relations between acute cyclic hypoxia and metastasis were studied by periodically exposing BALB/c nu/nu mice bearing A-07 human melanoma xenografts to a low oxygen atmosphere. The hypoxia treatment… CONTINUE READING
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