Tumorigenicity study of disodium glycyrrhizinate administered orally to mice.

  title={Tumorigenicity study of disodium glycyrrhizinate administered orally to mice.},
  author={Toshihiro Kobuke and Kunihiro Inai and Shigeru Nambu and Keiji Ohe and Tsuyoshi Takemoto and Kei Matsuki and Hajime Nishina and It Bau Huang and Shoji Tokuoka},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={23 11},
Disodium glycyrrhizinate (DG) was administered at concentrations of 0.15 (maximum tolerated dose), 0.08, 0.04 or 0% in the drinking-water to groups of 50, 70, 60 and 60 male B6C3F1 mice, respectively. Female groups, each consisting of 50 mice, were given DG in the drinking-water at concentrations of 0.3 (maximum tolerated dose), 0.15, 0.08 or 0%. Treatment was continued for 96 wk and the experiment was terminated at wk 110. There was no difference between treated and control groups in tumour… CONTINUE READING