Tumorigenicity of partial transformation mutants of Rous sarcoma virus.

@article{Kahn1982TumorigenicityOP,
  title={Tumorigenicity of partial transformation mutants of Rous sarcoma virus.},
  author={Patricia Kahn and Kiyoto Nakamura and Seung-il Shin and Ralph I Smith and Michael D Weber},
  journal={Journal of virology},
  year={1982},
  volume={42 2},
  pages={602-11}
}
Chicken embryo cells infected with partial transformation mutants of Rous sarcoma virus were tested for tumor-forming ability in chickens and in nude mice. Cells transformed by each of these partial transformation mutants display different combinations of transformation parameters. They therefore present a potentially favorable system for analyzing which properties of transformed cells are necessary for tumor formation. We found that the relative tumorigenicity of the virus mutants was… CONTINUE READING