Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency.

@article{Benedict1984TumorigenicityOH,
  title={Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency.},
  author={William F. Benedict and Bernard E. Weissman and Caroline S. Mark and Eric John Stanbridge},
  journal={Cancer research},
  year={1984},
  volume={44 8},
  pages={
          3471-9
        }
}
The tumorigenic capacity of hybrids formed by fusion of the highly tumorigenic HT1080 human fibrosarcoma cell line with nontumorigenic normal fibroblasts was examined. The HT1080 also contains an activated N-ras oncogene. Near-tetraploid hybrids which contained an approximately complete chromosomal complement from both parental cells were nontumorigenic when 1 X 10(7) cells were injected s.c. into athymic (nude) mice, whereas the parental HT1080 cells produced tumors in 100% of the animals with… CONTINUE READING

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