Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol.

@article{Wood1977TumorigenicityOF,
  title={Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol.},
  author={Alexander W. Wood and Wayne Levin and Raymond S L Chang and Roland E. Lehr and M Schaefer-Ridder and Jean M. Karle and Donald M. Jerina and Allan H. Conney},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 8},
  pages={3176-9}
}
Benz[a]anthracene and the five metabolically possible vicinal trans dihydrodiols of benz[a]anthracene were tested for ability to initiate skin tumors in CD-1 female mice. A single topical application of 0.4-2.0 mumol of hydrocarbon was followed 18 days later by twice weekly applications of the skin promoter 12-O-tetradecanoylphorbol-13-acetate. Comparisons of latency period, percent of mice with tumors, and number of papillomas observed per mouse indicated that benz[a]anthracene 1,2-, 5,6-, 8,9… CONTINUE READING