Tumorigenicity of embryonal carcinoma as an assay to study control of malignancy by the murine blastocyst.

@article{Pierce1979TumorigenicityOE,
  title={Tumorigenicity of embryonal carcinoma as an assay to study control of malignancy by the murine blastocyst.},
  author={G. Barry Pierce and S H Lewis and Gary J. Miller and Erik Moritz and Paul G Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 12},
  pages={6649-51}
}
A bioassay, based on tumorigenicity, has been developed to determine the mechanism whereby the blastocyst of the mouse controls malignant expression of embryonal carcinoma. The assay is based upon the incidence of tumors obtained when known numbers of cells of the 402AX strain of embryonal carcinoma are injected into strain 129 mice, compared to the incidence obtained when the same number of embryonal carcinoma cells are incorporated into Swiss-Webster blastocysts that are then injected in… CONTINUE READING

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