Tumorigenicity of SV40 T antigen immortalized human prostate epithelial cells: association with decreased epidermal growth factor receptor (EGFR) expression.

@article{Bae1994TumorigenicityOS,
  title={Tumorigenicity of SV40 T antigen immortalized human prostate epithelial cells: association with decreased epidermal growth factor receptor (EGFR) expression.},
  author={Victoria L. Bae and Colleen K. Jackson-Cook and Arthur R. Brothman and Susan J. Maygarden and Joy L. Ware},
  journal={International journal of cancer},
  year={1994},
  volume={58 5},
  pages={721-9}
}
Our primary objectives were to: 1) develop a system for the study of prostatic tumor evolution; and 2) examine the role of the epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) pathway in prostate tumor progression. Adult human prostate epithelial cells previously immortalized by transfection with the SV40 T antigen gene (P69SV40T) produced tumors in only 2/18 mice with a 6 month latency period. Reinjection of cells recovered from these tumors after 1 or 2 cycles of growth in… CONTINUE READING

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