Tumorigenicity of 6-halogenated derivatives of benzo[a]pyrene in mouse skin and rat mammary gland

@article{Cavalieri2004TumorigenicityO6,
  title={Tumorigenicity of 6-halogenated derivatives of benzo[a]pyrene in mouse skin and rat mammary gland},
  author={Ercole L Cavalieri and Eleanor G. Rogan and Paolo Cremonesi and Sheila M Higginbotham and Shahrokh Salmasi},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2004},
  volume={114},
  pages={10-15}
}
SummaryStudies of the tumorigenicity of 6-halogenated derivatives of benzo[a]pyrene (BP) can provide evidence about the role of the 6 position in the carcinogenic activation of BP. Female Swiss and A-strain mice were treated on the skin with BP, 6-fluorobenzo[a]pyrene (6-FBP), 6-chlorobenzo[a]pyrene (6-C1BP), 6-bromobenzo[a]pyrene (6-BrBP) and 6-iodobenzo[a]pyrene (6-IBP) by repeated application, and in some cases by initiation-promotion. While BP was more potent than 6-FBP, only these two… 
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