Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene

@article{Franksson1993TumorigenicityCT,
  title={Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene},
  author={Lars Franksson and Erica A. George and Simon J Powis and Geoff Butcher and Jeff Howard and Klas K{\"a}rre},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={177},
  pages={201 - 205}
}
Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules requires MHC-encoded molecules of the adenosine triphosphate binding cassette (ABC) family. Defects in these proteins represent a potential risk, since they are essential links in the machinery of T cell-mediated surveillance which continuously scrutinizes peptide samples of cellular proteins. Nevertheless, transfection of the mouse lymphoma mutant RMA-S with the rat ABC gene mtp2a (homologue to mouse… CONTINUE READING

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