Tumorigenicity Studies of Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) for the Treatment of Age-Related Macular Degeneration

@inproceedings{Kanemura2014TumorigenicitySO,
  title={Tumorigenicity Studies of Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) for the Treatment of Age-Related Macular Degeneration},
  author={Hoshimi Kanemura and Masahiro J. Go and Masayuki Shikamura and Naoki Nishishita and Noriko Sakai and Hiroyuki Kamao and Michiko Mandai and Chikako Morinaga and Masayo Takahashi and Shin Kawamata},
  booktitle={PloS one},
  year={2014}
}
Basic studies of human pluripotential stem cells have advanced rapidly and stem cell products are now seeing therapeutic applications. However, questions remain regarding the tumorigenic potential of such cells. Here, we report the tumorigenic potential of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of wet-type, age-related macular degeneration (AMD). First, immunodeficient mouse strains (nude, SCID, NOD-SCID and NOG) were tested for HeLa… CONTINUE READING