Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

@article{Land1983TumorigenicCO,
  title={Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes},
  author={H. Land and L. Parada and R. Weinberg},
  journal={Nature},
  year={1983},
  volume={304},
  pages={596-602}
}
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene. 
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