Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

@article{Connor1997TumorigenesisAA,
  title={Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation},
  author={F. Connor and D. Bertwistle and P. Mee and G. Ross and S. Swift and E. Grigorieva and V. Tybulewicz and A. Ashworth},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={423-430}
}
Germline mutation of the BRCA2 gene carries a high risk of developing breast cancer. To study the function of this gene, we generated a mutation in Brca2 in mice. Unlike other mutations in the Brca2 gene, which are lethal early in embryogenesis when homozygous, some of our homozygous mutant mice survive to adulthood. These animals have a wide range of defects, including small size, improper differentiation of tissues, absence of germ cells and the development of lethal thymic lymphomas… Expand
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