Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.

@article{Ko2007TumoralAE,
  title={Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.},
  author={Jinyoung Ko and Kyeongsoon Park and Yoo-Shin Kim and Min Sang Kim and Jong Kwon Han and Kwangmeyung Kim and R K Park and In-San Kim and Hyun Kyu Song and Doo Sung Lee and Ick Chan Kwon},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={123 2},
  pages={109-15}
}
The main objective of this study was to develop and characterize a pH-responsive and biodegradable polymeric micelle as a tumor-targeting drug delivery system. The pH-responsive block copolymer was synthesized by a Michael-type step polymerization of hydrophilic methyl ether poly(ethylene glycol) (MPEG) and pH-responsive and biodegradable poly(beta-amino ester), resulting in an amphiphilic MPEG-poly(beta-amino ester) block copolymer. This copolymer, which formed nano-sized self-assembled… CONTINUE READING
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