Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs.

@article{Corti2004TumorVT,
  title={Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs.},
  author={Angelo Corti and Mirco Ponzoni},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1028},
  pages={104-12}
}
The poor selectivity of chemotherapeutic drugs for neoplastic cells may lead to dose-limiting side effects that compromise clinical outcomes. Moreover, heterogeneous tumor perfusion and vascular permeability, and increased interstitial pressure, could represent critical barriers that limit the penetration of drugs into neoplastic cells distant from tumor vessels and, consequently, the effectiveness of chemotherapy. We have recently developed two strategies for increasing the local concentration… CONTINUE READING

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